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A novel glycoprotein obtained from Chlorella vulgaris pressure CK22 reveals antimetastatic immunopotentiation.

PMID: 

Most cancers Immunol Immunother. 1998 Feb ;45(6):313-20. PMID: 9490201

Summary Title: 

A novel glycoprotein obtained from Chlorella vulgaris pressure CK22 reveals antimetastatic immunopotentiation.

Summary: 

A glycoprotein extract (CVS), derived from the unicellular inexperienced alga Chlorella vulgaris, pressure CK22, exhibited a pronounced antitumor impact in opposition to each spontaneous and experimentally induced metastasis in mice. Inhibition of tumor metastasis was enhanced when intratumor administration of CVS was adopted by s.c. injection of CVS. Anti-metastatic immunopotentiation was noticed in euthymic mice, however not in athymic nude mice. The antitumor exercise of CVS was mirrored in antigen-specific, T-cell-mediated immunity. Each CD4 and CD8 T cells contributed to the antimetastatic results, as proven by in vivo depletion experiments with anti-T-cell subset antibodies. Moreover, CVS triggered the recruitment of T cells to the regional lymph nodes and their proliferation in these organs. The CD4-positive inhabitants, following CVS injection on the time of tumor rechallenge, displayed a pronounced improve within the proportion of T cells that have been CD18 brilliant, CD44 brilliant, CD25+, CD54+, CD69+ or CD71+ within the lymph nodes. Thus, CVS induces T cell activation in peripheral lymph nodes in tumor-bearing mice. We conclude that CVS augments antimetastatic immunity via T cell activation in lymphoid organs and enhances recruitment of those cells to the tumor websites. Presurgical remedy with CVS would possibly forestall metastasis or tumor development.

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