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Chlorella vulgaris induces apoptosis of human non-small cell lung carcinoma.


Med Chem. 2017 ;13(6):560-568. PMID: 28494726

Summary Title: 

Chlorella vulgaris Induces Apoptosis of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells.


OBJECTIVE: Chlorella vulgaris (C. vulgaris), a unicellular inexperienced microalga, has been extensively used as a meals complement and reported to have antioxidant and anticancer properties. The present examine was designed to evaluate the cytotoxic, apoptotic, and DNA-damaging results of C. vulgaris progress issue (CGF), scorching water C. vulgaris extracts, inlung tumor A549 and NCI-H460 cell strains.METHODS: A549 cells, NCI-H460 cells, and regular human fibroblasts have been handled with CGF at numerous concentrations (0-300μg/ml) for twenty-four hr. The comet assay andγH2AX assay confirmed DNA harm in A549 and NCI-H460 cells upon CGF publicity. Analysis of apoptosis by the TUNEL assay and DNA fragmentation evaluation by agarose gel electrophoresis confirmed that CGF induced apoptosis in A549 and NCI-H460 cells.RESULTS: Chlorella vulgaris scorching water extract induced apoptosis and DNA harm in human lung carcinoma cells.CONCLUSION: CGF can thus be thought-about a possible cytotoxic or genotoxic drug for remedy of lung carcinoma.

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