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Docetaxel Improves Prostate Most cancers-Particular Survival in Sure Sufferers

Including docetaxel to straightforward remedy can delay prostate cancer-specific survival in sure sufferers, in line with a meta-analysis revealed in JAMA Community Open.

Researchers discovered that docetaxel decreased the chance of prostate cancer-specific dying in sufferers with nonmetastatic prostate most cancers who had prostate-specific antigen (PSA) ranges under 4 ng/mL, Gleason scores of 8 to 10, and an ECOG efficiency standing rating of 0.

This meta-analysis included sufferers with nonmetastatic prostate most cancers who had been enrolled in 4 randomized managed trials. A complete of 145 sufferers had PSA ranges lower than 4 ng/mL and Gleason scores of 8 to 10, making them eligible for evaluation. Most sufferers (95.9%) had an ECOG efficiency standing rating of 0, however 4.1% had a rating of 1.


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Sufferers had acquired normal remedy — radical prostatectomy alone or radiotherapy and androgen deprivation remedy — with docetaxel (n=78) or with out it (n=67).

In an adjusted evaluation, there was no vital distinction within the danger of all-cause dying between sufferers who acquired docetaxel and people who didn’t. This was true within the total cohort (hazard ratio [HR]0.51; 95% CI, 0.24-1.09) and amongst sufferers with a efficiency standing of 0 (HR, 0.46; 95% CI, 0.21-1.02).

Within the total cohort, there was no vital distinction within the danger of prostate cancer-specific dying between sufferers who acquired docetaxel and people who didn’t (HR, 0.42; 95% CI, 0.17-1.02).

Nonetheless, sufferers with a efficiency standing of 0 had a big discount within the danger of prostate cancer-specific dying in the event that they acquired docetaxel (HR, 0.30; 95% CI, 0.11-0.86). The unadjusted 8-year prostate cancer-specific mortality fee was 8% with docetaxel plus normal care and 23% with normal care alone.

Based mostly on these outcomes, the researchers concluded that including docetaxel to straightforward remedy has the potential to enhance prognosis in sufferers with nonmetastatic prostate most cancers who’re in in any other case good well being, have a PSA stage of lower than 4 ng/mL, and have a Gleason rating of 8 to 10.

Disclosures: Some examine authors declared affiliations with biotech, pharmaceutical, and/or system firms. Please see the unique reference for a full record of disclosures.

Reference

Mahal BA, Kwak L, Xie W, et al. Mortality danger for docetaxel-treated, high-grade prostate most cancers with low PSA ranges: A meta-analysis. JAMA Netw Open. Revealed on-line November 1, 2023. doi:10.1001/jamanetworkopen.2023.40787

This text initially appeared on Most cancers Remedy Advisor

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