Natural Remedies

Ginkgolide B reduces neuronal cell apoptosis within the hemorrhagic mind.


J Ethnopharmacol. 2011 Oct 11 ;137(3):1462-8. Epub 2011 Aug 22. PMID: 21878382

Summary Title: 

Ginkgolide B reduces neuronal cell apoptosis within the hemorrhagic rat mind: potential involvement of Toll-like receptor 4/nuclear factor-kappa B pathway.


ETHNOPHARMACOLOGICAL RELEVANCE: Ginkgolide B (GB) is without doubt one of the ginkgolides which have been remoted from leaves and root bark of the Chinese language tree Ginkgo biloba L. (Ginkgoaceae), and is a particular and potent antagonist of platelet activating issue. There’s a massive physique of knowledge exhibiting that GB possesses a markedly neuroprotective property towards ischemia-induced impairment in vivo and in vitro. Lately it has been discovered that GB can inhibit the irritation within the rat mind tissues with ischemia/reperfusion harm and within the astrocytes handled with lipopolysaccharide, in addition to shield neurons towards beta-amyloid 25-35 and ischemia-induced apoptosis. Nevertheless, there have been few studies on the affect of GB on intracerebral hemorrhage (ICH). This research was to analyze the results of intraperitoneal GB on neuronal cell apoptosis, inflammatory cytokines and Toll-like receptor 4 (TLR4)/nuclear issue kappa-B (NF-κB) pathway after ICH.MATERIALS AND METHODS: Wistar rats obtained an intraperitoneal injection of 5, 10 and 20mg/kg GB after ICH as soon as a day until day 5. Rats had been sacrificed by decapitation at hour 2, 6 and 12, in addition to day 1, 2, 3 and 5 after ICH. Gene expressions of TLR-4 and NF-κB, concentrations of tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) in addition to variety of apoptotic neuronal cells in hemorrhagic rat mind tissues had been decided.RESULTS: The administration of 10 and 20mg/kg GB might considerably suppress gene expressions of TLR-4 and NF-κB, reduce concentrations of TNF-α, IL-1βand IL-6 in addition to cut back variety of apoptotic neuronal cells in hemorrhagic rat mind tissues by Least-significant Distinction take a look at (P0.05). Nevertheless, a transparent concentration-response relationship was not discovered.CONCLUSIONS: GB could inhibit TLR4/NF-κB-dependent inflammatory responses, and moreover reduce neuronal cell apoptosis after ICH, which can help the usage of G. biloba extracts for the remedy of ICH.

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