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Ginkgolides defend main cortical neurons from potassium cyanide-induced hypoxic harm.

PMID: 

Exp Mind Res. 2007 Jun ;179(4):665-71. Epub 2007 Jan 16. PMID: 17225090

Summary Title: 

Ginkgolides defend main cortical neurons from potassium cyanide-induced hypoxic harm.

Summary: 

On this research, we investigated the results of ginkgolides (Gins A, B, C and J), the principle constituent of the non-flavone fraction of EGb 761, on hypoxic harm induced by potassium cyanide (KCN) in main cortical neurons. The neurons have been pretreated with or with out ginkgolides for twenty-four h earlier than incubation with KCN for 4 h. Cell viability was then decided by a MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyletrazolium bromide]assay and lactate dehydrogenase (LDH) launch from neurons into the medium was measured. The morphological adjustments of neurons have been noticed below inverse microscopy and electron microscopy. The outcomes demonstrated that KCN (0.05 mmol/l) considerably decreased cell viability and elevated LDH launch (P

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