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Iodine-Induced Hypothyroidism Linked to Elevated Coronary heart Failure Danger

The incidence of hypothyroidism after iodine publicity is related to elevated threat for incident coronary heart failure, in response to research findings revealed within the Journal of the American Coronary heart Affiliation.

Though most people can adapt to the surplus iodine publicity from iodinated distinction media, a latest research reported an almost 40% elevated threat for thyroid dysfunction inside 60 days of receiving iodine distinction. Hypothyroidism is related to numerous cardiovascular threat elements, however the relationship between iodine-induced hypothyroidism and these elements stays understudied.

To evaluate the connection between iodine exposure-induced hypothyroidism and cardiac occasions, researchers performed a population-based research utilizing data from the Veterans Affairs Company Knowledge Warehouse between 1998 and 2021. Members have been adults aged no less than 18 years with a file of serum thyroid-stimulating hormone (TSH) ranges inside 60 days of iodine distinction administration.

Exclusion standards included a historical past of hypothyroidism, hyperthyroidism, atrial fibrillation, coronary heart failure, thyroid surgical procedure, thyroid most cancers, and use of antithyroid drugs.

Proceed Studying

The first publicity was iodine-induced hypothyroidism in response to site-specific reference ranges of serum thyrotropin. The researchers outlined the end result of coronary heart failure in response to Worldwide Classification of Illnesses codes.

The research included a complete of 45,470 members (imply age, 61.1 years; SD, 14.1), of whom 88% have been males, 63% have been White, 68% had hypertension, 62% had dyslipidemia, 36% had diabetes, and 26% had coronary coronary heart illness. Amongst these members, 7.4% developed hypothyroidism inside 60 days after iodine distinction administration.

The euthyroid and hypothyroid teams had common serum TSH ranges of 1.78 mIU/L (SD, 0.93) and 6.73 mIU/L (SD, 6.81), respectively. In contrast with members within the euthyroid group, these within the hypothyroid group have been extra more likely to be older and non-Hispanic White adults and have the next prevalence of comorbidities.

Throughout a median follow-up of three.6 years (interquartile vary, 1.9-7.2), new-onset coronary heart failure was noticed amongst 12.5% of members. The researchers discovered associations between elevated threat for incident coronary heart failure and:

  • Hypothyroidism (adjusted hazard ratio [aHR]1.11; 95% CI, 1.01-1.22; P =.047);
  • Subclinical hypothyroidism (aHR, 1.26; 95% CI, 1.04-1.52; P =.016); and,
  • Elevated TSH ranges lower than 7.5 mIU/L (aHR, 1.24; 95% CI, 1.02-1.52; P =.033)

The researchers famous no affiliation between incident coronary heart failure and overt hypothyroidism (aHR, 0.92; 95% CI, 0.53-1.59; P =.76) or elevated TSH ranges of no less than 7.5 mIU/L (aHR, 1.26; 95% CI, 0.84-1.88; P =.27) in contrast with the euthyroid group.

Within the subgroup analyses stratified by intercourse and race, the affiliation between threat for incident coronary heart failure and hypothyroidism was stronger amongst girls (HR, 1.65; 95% CI, 1.13-2.40; P =.02) and Black people (HR, 1.38; 95% CI, 1.11-1.70; P =.05) in contrast with the research inhabitants.

Research limitations embrace potential confounding, potential misclassification of knowledge, and potential choice bias when clinicians examined for thyroid dysfunction.

“[T]his study demonstrates that in a predominantly male population of US adults, hypothyroidism following routine iodine contrast administration was associated with an 11% increased risk of incident heart failure over a median follow-up of 3.6 years,” the researchers concluded. “We urge for further research to robustly study the clinical significance of this issue, including the investigation of this topic in more sex-diverse populations.”


Inoue Ok, Guo R, Lee ML, et al. Iodine-induced hypothyroidism and long-term dangers of incident coronary heart failure.J Am Coronary heart Assoc. Printed on-line October 10, 2023. doi:10.1161/JAHA.123.030511

This text initially appeared on Endocrinology Advisor

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