Women's Health

Lisa Mosconi’s Menopause Mind Analysis Makes Case for Hormone Remedy – SheKnows

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As Lisa MosconiPh.D delivered her final remarks throughout her TED Speak in December 2019, she appeared shocked, nearly caught off guard by the viewers’s response. “Brain health is women’s health,” she says to the viewers when the room erupted into applause and rose from their seats to present her a standing ovation.

Throughout the earlier 13 minutes, Mosconi, the Director of the Weill Cornell Girls’s Mind Initiative (WBI) and Affiliate Director of the Alzheimer’s Prevention Clinic, Mosconi had earned that reward by laying out a easy premise: that when it got here to Alzheimer’s, ladies have been practically two-thirds larger threat of creating the illness in comparison with males. Why? “It turns out our brains age differently, and menopause plays a key role here for women,” she explains within the video.

Estrogen, we study, is vital for each replica and mind operate. “The health of the ovaries is linked to the health of the brain.” So when a lady’s ranges of estrogen decline in midlife, it disrupts a lady’s life with signs like scorching flashessleep deprivation, night time sweats, and extra. Then again, she deadpans, “men’s testosterone doesn’t run out until late in life, which is a slow and pretty much symptom-free process, of course.”

Since its launch, Mosconi’s presentation has garnered greater than 4 million views, serving to to boost consciousness about menopause and the intersectional method the medical institution should use to guard ladies through the organic transition. By her analysis and publications, Mosconi advises ladies to consider their brains as an organ to guard. In her 2018 e book, Mind Meals: The Shocking Science of Consuming for Cognitive Energythe neuroscientist explains how one can combat cognitive decline with nutritious components that come largely from the Mediterranean Food plan.

She adopted up in late 2022 together with her influential e book, The XX Mind: The Groundbreaking Science Empowering Girls to Maximize Cognitive Well being and Stop Alzheimer’s Illness. In some ways, the e book is a name to motion in that it urges ladies to take management of their well being by implementing behaviors round diet, train and sleep that can shield and restore mind well being.

menopause brain

In early 2024, the neuroscientist will publish The Menopause Mind: New Science Empowers Girls to Navigate the Pivotal Transition with Data and Confidence. On this e book, Mosconi makes a daring case for the advantages of hormonal therapies to assist shield ladies’s brains and beginning earlier than menopause signs arrive or early on in addition to all through the menopausal journey. She additionally highlights the potential advantages of selective estrogen receptor modulators (SERMs), plant- or animal-sourced variations that mimic estrogen. “These preparations are specifically engineered to target one organ — the brain,” she informed CNN in a latest interview. “It’s kind of genius because you really want an estrogen that goes straight to your brain and does not impact your reproductive organs and raise the risk of cancer.”

Earlier than Mosconi can scale her resolution, she’ll have to chop by way of the continued controversy surrounding hormonal remedy as a secure and viable choice to deal with menopause signs and to guard ladies’s well being. Nonetheless, a latest meta evaluation co-authored by Mosconi and different researchers checked out 50-plus research and noticed promising outcomes. Their evaluate indicated that ladies who took hormone remedy in midlife to deal with menopause signs have been much less prone to develop dementia.

In the meantime, ladies who took hormone remedy after the age of 65 didn’t decrease their possibilities of creating dementia. “We need more clinical trials evaluating the effects of midlife hormone therapy on biological indicators of Alzheimer’s diseasewhich we can now measure using brain imaging and fluids such as blood,” she mentioned lately.


Mosconi is urgent on and is already at work on one other examine together with her colleagues to take a look at PhytoSerm, a plant-derived model of estrogen, and the way it impacts the earliest presence of Alzheimer’s within the midlife mind. “The more women demand this information, the sooner we’ll be able to break the taboos around menopause, and also come up with solutions that actually work, not just for Alzheimer’s disease, but for women’s brain health as a whole.”

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