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Norwegian research seems at which medicines finest stop migraine

Migraine is greater than only a headache. Usually the ache is accompanied by nausea, vomiting, gentle sensitivity, and sound sensitivity. Persistent migraine may be disabling and will stop many, particularly ladies, from contributing to working life.

Nonetheless, it typically takes a very long time for migraine sufferers to discover a therapy that works effectively for them. Researchers on the Norwegian Heart for Headache Analysis (NorHead) have used information from the Norwegian Prescription Register to take a look at which medicines finest stop migraine in folks in Norway:

There has now been finished numerous analysis on this topic earlier than. This may occasionally weaken the standard of the therapy and enhance the price of therapy for this affected person group.”

Marte-Helen Bjørk, Research Chief, Professor, Division of Medical Drugs, College of Bergen

Three medicines had higher impact than the primary selection of medicines.

The researchers used nationwide register information from 2010 to 2020 to estimate therapy impact. They measured this by trying on the consumption of acute migraine medicines earlier than and after beginning preventive therapy, and investigated how lengthy the folks with migraine used the completely different preventive remedies. A complete of over 100 thousand migraine sufferers had been within the research.

“When the withdrawal of acute migraine medicines changed little after starting preventive medicines, or people stopped quickly on the preventive medicines, the preventive medicine was interpreted as having little effect. If the preventive medicine was used on long, uninterrupted periods, and we saw a decrease in the consumption of acute medicines, we interpreted the preventive medicine as having good effect”, Bjørk explains.

As a rule, so-called beta blockers are used as the primary selection to forestall migraine assaults, however the researchers discovered that particularly three medicines had higher preventive impact than these: CGRP inhibitors, amitriptyline and simvastatin.

“The latter two medicines are also established medicines used for depression, chronic pain and high cholesterol, respectively, while CGRP inhibitors are developed and used specifically for chronic migraine”, says the professor.

Can have nice significance for the price of well being care.

CGRP inhibitors are costlier than the opposite medicines. In 2021 their reimbursement amounted to 500 million NOK (not together with reductions given by pharma firms).

“Our analysis shows that some established and cheaper medicines can have a similar treatment effect as the more expensive ones. This may be of great significance both for the patient group and Norwegian health care”, says Bjørk.

The researchers at NorHead have already began work on a big scientific research to measure the impact of established cholesterol-lowering medicines as a safety measure towards persistent and episodic migraine.


Journal reference:

Bjørk, MH, et al. (2023). Comparative retention and effectiveness of migraine preventive remedies: A nationwide registry‐primarily based cohort research. European Journal of Neurology.

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