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The results of vitamin C supplementation on glycemic management in sufferers with kind 2 diabetes.


Diabetes Metab Syndr. 2023 Aug ;17(8):102824. Epub 2023 Jul 7. PMID: 37523928

Summary Title: 

The results of vitamin C supplementation on glycemic management in sufferers with kind 2 diabetes: A scientific overview and meta-analysis.


BACKGROUND AND AIM: It has been instructed that taking vitamin C dietary supplements could enhance glycemic management in sufferers with kind 2 diabetes mellitus (T2DM). Nevertheless, there has not been a radical analysis of the particular influence or certainty of the findings. This systematic overview and meta-analysis was carried out to find out the impact of vitamin C supplementation on glycemic profile in T2DM sufferers.METHODS: A scientific search was carried out throughout on-line databases together with Scopus, Internet of Science, and PubMed/Medline to establish related randomized managed trials (RCTs) printed till July 2022. A random-effects mannequin was utilized for the meta-analysis.RESULTS: The current meta-analysis included a complete of twenty-two RCTs with 1447 sufferers identified with T2DM.A pooled evaluation revealed a major lower in ranges of serum hemoglobin A1c (HbA1c), fasting insulin, and fasting blood glucose (FBG) in vitamin C-treated T2DM sufferers in contrast with their untreated counterparts. The dose-response analysis displayed a considerable linear affiliation between the intervention period and adjustments in serum HbA1c ranges. Nevertheless, the evaluation didn’t reveal any important impact of vitamin C on serum values of homeostasis mannequin evaluation of insulin resistance(HOMA-IR) in diabetic sufferers. Subgroup analyses indicated that high-dose vitamin C administration (≥1000 mg/d) significantly decreased serum HOMA-IR ranges.CONCLUSION: These findings counsel that long-term (≥12 weeks) and high-dose vitamin C supplementation (≥1000 mg/d) could ameliorate glycemic profile in T2DM sufferers. Nevertheless, extra high-quality RCTs are essential to validate these outcomes.

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