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The protecting impact of crocin towards testicular toxicity induced by ionizing radiation.

PMID: 

Environ Toxicol. 2023 Aug 24. Epub 2023 Aug 24. PMID: 37615252

Summary Title: 

The protecting impact of crocin towards testicular toxicity induced by ionizing radiation through AKT/FOXO pathway.

Summary: 

Crocin, a pharmacologically energetic part of Crocus sativus L. (saffron), has been knowledgeable to be helpful within the remedy of stress-related oxidative impairment. Within the current research, we examined the protecting function of crocin towards testicular injury induced by radiation (acute and fractionated) and the alteration of the AKT/FOXO signaling pathway. Male Wister albino rats have been uncovered to acute dose of 6 Gy and a fractionated dose of gamma radiation (2 Gy each 2 days as much as 6 Gy complete doses). Rats have been pretreated intraperitoneally with crocin in a dose of fifty mg/kg for seven consecutive days previous to publicity to irradiation at a degree of 6 Gy and through the fractionated irradiation of rats. Management teams have been run concurrently. Ionizing radiation brought on adjustments within the degree of oxidative stress biomarkers manifested as elevation of thiobarbituric acid reactive substance, complete nitrate/nitrite and reactive oxygen species (ROS) related to a lower in catalase in addition to within the degree of inflammatory parameters (lower in expression of Nrf2 which was associated to a big improve in expression of NF-κB p65). Irradiation produced mobile injury characterised by a rise in serum lactate dehydrogenase. These findings have been aligned with elevated expression of the forkhead field O-1 (FOXO-1) and activation of protein kinase B (AKT) pathway. Irradiation of rats led to discount in serum testosterone degree and testicular weights. Pretreatment with the indicated dose of crocin shielded towards the adjustments in all of the evaluated parameters. Administration of crocin could be launched as a novel preclinical strategy for regulation of testicular injury induced by radiation; through controlling the continuing oxidative stress and inflammatory response in addition to activation FOXO/AKT signaling pathway.

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