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Vaginal Estrogen Remedy Does Not Improve Threat of Demise in Breast Most cancers Sufferers

Vaginal estrogen remedy doesn’t enhance the chance of demise in sufferers with breast most cancers, in line with analysis printed in JAMA Oncology.

In reality, researchers discovered modest decreases within the threat of breast cancer-specific demise and all-cause demise amongst sufferers who used vaginal estrogen remedy.

On this population-based examine, researchers examined knowledge from nationwide most cancers registries in Scotland and Wales for 49,237 girls identified with breast most cancers between the ages of 40 and 79 years.


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After breast most cancers analysis, 5% of sufferers used vaginal estrogen remedy, and 1% obtained systemic hormone substitute remedy (HRT).

There have been 5795 breast cancer-specific deaths at a median follow-up of 5 years within the Scotland cohort and eight years within the Wales cohort.

In an adjusted evaluation, there was a modest lower within the threat of breast cancer-specific demise amongst sufferers who used vaginal estrogen remedy (hazard ratio [HR]0.77; 95% CI, 0.63-0.94; P =.01).

Outcomes had been comparable whether or not sufferers obtained 1-4 vaginal estrogen remedy prescriptions (HR, 0.81; 95% CI, 0.67-0.99; P =.04) or 5 or extra prescriptions (HR, 0.57; 95% CI, 0.34-0.96; P =.03).

There was no vital affiliation with lower-dose vaginal estrogen remedy (HR, 0.77; 95% CI, 0.56-1.07; P =.12) or higher-dose remedy (HR, 0.81; 95% CI, 0.55-1.21; P =.31).

The researchers additionally discovered no vital affiliation between systemic HRT use and breast cancer-specific demise (HR, 0.98; 95% CI, 0.68-1.40; P =.90).

Likewise, there was no vital affiliation between vaginal estrogen use and cardiovascular demise (aHR, 0.78; 95% CI, 0.28-2.16), however there was a modest lower within the threat of all-cause demise amongst vaginal estrogen customers (aHR, 0.80; 95% CI, 0.71-0.90).

These findings “may provide some reassurance to prescribing clinicians and support the guidelines suggesting that vaginal estrogen therapy can be considered in patients with breast cancer and genitourinary symptoms if nonhormonal treatments are unsuccessful,” the researchers concluded.

Disclosures: One of many examine authors declared affiliations with biotech, pharmaceutical, and/or machine corporations. Please see the unique reference for a full checklist of disclosures.

Reference

McVicker L, Labeit AM, Coupland CAC, et al. Vaginal estrogen remedy use and survival in females with breast most cancers. JAMA Oncol. Revealed on-line November 2, 2023. doi:10.1001/jamaoncol.2023.4508

This text initially appeared on Most cancers Remedy Advisor

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