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Vitamin E and its molecular results in experimental fashions of neurodegenerative illnesses.


Int J Mol Sci. 2023 Jul 7 ;24(13). Epub 2023 Jul 7. PMID: 37446369

Summary Title: 

Vitamin E and Its Molecular Results in Experimental Fashions of Neurodegenerative Ailments.


With the development of in vivo research and medical trials, the pathogenesis of neurodegenerative illnesses has been higher understood. Nonetheless, gaps nonetheless should be higher elucidated, which justifies the publication of evaluations that discover the mechanisms associated to the event of those illnesses. Research present that vitamin E supplementation can shield neurons from the harm attributable to oxidative stress, with a optimistic impression on the prevention and development of neurodegenerative illnesses. Thus, this assessment goals to summarize the scientific proof of the results of vitamin E supplementation on neuroprotection and on neurodegeneration markers in experimental fashions. A seek for research revealed between 2000 and 2023 was carried out within the PubMed, Net of Science, Digital Well being Library (BVS), and Embase databases, during which the results of vitamin E in experimental fashions of neurodegeneration had been investigated. A complete of 5669 doubtlessly eligible research had been recognized. After excluding the duplicates, 5373 remained, of which 5253 had been excluded after checking the titles, 90 articles after studying the abstracts, and 11 after totally reviewing the manuscripts, leaving 19 publications to be included on this assessment. Experiments with in vivo fashions of neurodegenerative illnesses demonstrated that vitamin E supplementation considerably improved reminiscence, cognition, studying, motor perform, and mind markers related to neuroregeneration and neuroprotection. Vitamin E supplementation decreased beta-amyloid (Aβ) deposition and toxicity in experimental fashions of Alzheimer’s illness. As well as, it decreased tau-protein hyperphosphorylation and elevated superoxide dismutase and brain-derived neurotrophic issue (BDNF) ranges in rodents, which appears to point the potential use of vitamin E in stopping and delaying the progress of degenerative lesions within the central nervous system.

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