Pachymic acid protects in opposition to bleomycin-induced pulmonary fibrosis.
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PMID:
Appl Biochem Biotechnol. 2023 Aug 31. Epub 2023 Aug 31. PMID: 37650950
Summary Title:
Pachymic Acid Protects In opposition to Bleomycin-Induced Pulmonary Fibrosis by Suppressing Fibrotic, Inflammatory, and Oxidative Stress Pathways in Mice.
Summary:
Pachymic acid (PA), a pure extract from Poria cocos (Schw.) Wolf, possesses anti-inflammatory and anti-oxidative properties. Nevertheless, it’s nonetheless unknown whether or not PA can shield in opposition to bleomycin (BLM)-induced pulmonary fibrosis (PF). On this examine, we investigated the consequences of PA in mice administered BLM. Our outcomes confirmed that PA considerably improved lung injury and pathological manifestations. Moreover, PA diminished the degrees of interleukin (IL)-6 and tumor necrosis issue (TNF)-α, whereas growing the extent of IL-10. PA additionally decreased the degrees of hydroxyproline and malondialdehyde, and elevated the actions of superoxide dismutase and glutathione peroxidase in lung tissue. Moreover, PA inhibited the will increase in pyrin domain-containing protein 3 (NLRP3), ASC, IL-1β, P20, and TXNIP induced by BLM. In conclusion, our examine demonstrated the protecting results of PA in opposition to BLM-induced PF in mice by suppressing fibrotic, inflammatory, and oxidative stress pathways.
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