Prostate most cancers outcomes comparable for transgender ladies, cisgender males
Most prostate most cancers outcomes don’t differ considerably between transgender ladies (TGW) and cisgender (CG) males, together with prostate cancer-specific mortality, in keeping with a research printed on-line July 21 in Most cancers.
Margaret Meagher, M.D., from the College of California San Diego College of Medication in La Jolla, and colleagues in contrast oncological traits and survival outcomes between TGW and CG males with prostate most cancers utilizing knowledge from the Veterans Affairs Informatics and Computing Infrastructure database (1999 to 2020) and the Surveillance, Epidemiology, and Finish Outcomes-Medicare database (2010 to 2017). The teams had been matched in a 5:1 ratio (CG:TGW) based mostly on age, race, yr of analysis, and Charlson Comorbidity Index rating. Information had been included for 1,194 sufferers: 199 TGW and 995 CG.
The researchers discovered that there have been no important associations between transgender id and metastatic presentation, high-risk localized illness, or prostate cancer-specific mortality. There was a major affiliation seen between transgender id and improved total survival.
“In distinction to earlier research, we didn’t detect worsened prostate most cancers outcomes inside [the transgender] group,” the authors write. “These conflicting data highlight the need for further investigation.”
A number of authors disclosed ties to the biopharmaceutical trade.
Extra info:
Margaret Meagher et al, Prostate most cancers in transgender ladies: A propensity rating–matched evaluation of illness severity and survival, Most cancers (2024). DOI: 10.1002/cncr.35469
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