Sesamol attenuates bleomycin-induced pulmonary toxicity and fibrosis.
PMID:
J Biochem Mol Toxicol. 2023 Jul 18:e23472. Epub 2023 Jul 18. PMID: 37462223
Summary Title:
Sesamol attenuates bleomycin-induced pulmonary toxicity and fibrosis in experimental animals.
Summary:
Sesamol, a lignan obtained from roasted seeds of Sesamum indicum, has excessive antioxidant and anti inflammatory exercise. On this research, we now have investigated the impact of sesamol on Bleomycin (BLM) induced pulmonary toxicity in addition to fibrosis in Wistar rats. Lung toxicity was induced by administration of BLM, 0.015 U/g ip, twice weekly for 28 days whereas lung fibrosis was induced by BLM, 0.015 U/g ip, each fifth day for 49 days. Sesamol administration was began 7 days earlier than first dose of BLM in each the fashions. It was noticed that sesamol 50 mg/kg most successfully attenuated pulmonary toxicity by lowering oxidative stress, irritation and apoptosis. This dose was additional evaluated for its anti-fibrotic impact. It was noticed that there was a major discount in fibrosis. Lung collagen content material was markedly lowered. Moreover, expression of pro-fibrotic proteins, TGF-β/SMAD andα-SMA, was lowered and that of anti-fibrotic protein, AMPK, was markedly elevated. Despite the fact that the mixture of sesamol with pirfenidone exhibited no extra safety than both drug alone, it’s evident from our research that our take a look at drug, sesamol is comparable in efficacy to pirfenidone. Thus, sesamol has promising therapeutic potential in remedy of pulmonary toxicity and fibrosis.
