Utility of vitamin C in ameliorating citalopram-induced testicular toxicity.
PMID:
J Biochem Mol Toxicol. 2023 Oct 4:e23543. Epub 2023 Oct 4. PMID: 37794744
Summary Title:
Utility of vitamin C in ameliorating citalopram-induced testicular toxicity through modulating nitro-oxidative stress and apoptosis in mice.
Summary:
There’s a rising concern that antidepressant medicine impair sexual operate and adversely affect spermatogenesis and male fertility. Vitamin C is a pure antioxidant that performs a significant function within the male reproductive system. The current examine investigated the ameliorating potential of vitamin C in opposition to citalopram (CTL)-evoked testicular toxicity and spermatogenesis impairment in mice. Mice had been randomly divided into six teams: management, CTL, vitamin C 100, vitamin C 200, CTL plus vitamin C 100, and CTL plus vitamin C 200. Grownup male mice had been intraperitoneally (ip) injected with 10 mg/kg of CTL for 35 days with or with out vitamin C. On the finish of the examine, physique and testes weight, sperm parameters, histopathology of testes, testosterone degree, testicular ranges of malondialdehyde (MDA), nitric oxide (NO), whole antioxidant capability (TAC), and apoptosis (TUNEL assay) had been evaluated. Our findings revealed that vitamin C restored spermatogenesis by bettering sperm rely, motility, viability, morphology, and chromatin integrity. Testosterone ranges and testes histopathology had been considerably improved within the vitamin C-administrated teams. Moreover, vitamin C administration markedly alleviated CTL-induced nitro-oxidative injury, enhancing TAC ranges, and lowering NO and MDA ranges. While CTL remedy induced a big enhance within the variety of TUNEL-positive cells in comparison with the management, the administration of vitamin C considerably prevented the apoptotic results of CTL. Collectively, vitamin C remedy protects in opposition to CTL-induced testicular injury through mitigating nitro-oxidative stress and apoptosis, which offers proof for vitamin C as a useful remedy in opposition to antidepressant drug-associated reproductive toxicity and male sub/infertility.
