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Apocynin alleviates weight achieve and obesity-induced adipose tissue irritation in high-fat weight loss plan.


Phytother Res. 2023 Aug ;37(8):3481-3494. Epub 2023 Could 17. PMID: 37194916

Summary Title: 

Apocynin alleviates weight achieve and obesity-induced adipose tissue irritation in high-fat diet-fed C57BL/6 mice.


Weight problems includes persistent low-grade irritation inside adipose tissue. Apocynin (APO) is a therapeutic agent for the remedy of inflammatory ailments. Due to this fact, the current research aimed to analyze whether or not APO can scale back weight achieve and obesity-induced adipose tissue irritation. C57BL/6 mice had been administered APO or orlistat (Orli) as a constructive management with a high-fat weight loss plan (HFD) for 12 weeks. Lipopolysaccharide-stimulated 3T3-L1 adipocytes had been used for the in vitro research. Our outcomes confirmed a considerably decrease white adipose tissue (WAT) mass index in 10 mg/kg APO-treated mice than in 20 mg/kg Orli-treated mice. Furthermore, the protein expression of adipose triglyceride lipase, fatty acid synthase, sterol regulatory element-binding transcription issue 1, and peroxisome proliferator-activated receptorγwas reversed within the WAT of 10 mg/kg APO-treated mice. Moreover, APO lowered the expression of the macrophage marker F4/80, decreased the mRNA ranges of tumor necrosis factor-αand monocyte chemoattractant protein-1, and elevated the mRNA ranges of interleukin-10 in WAT. APO decreased the phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase, and p65 in vivo and in vitro. Notably, APO had a stronger impact on the amelioration of adipose tissue irritation than Orli did. Our findings lay the muse for analysis on using APO as an agent to ameliorate weight achieve and obesity-induced inflammatory ailments.

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