PMID:
Exp Ther Med. 2020 Apr ;19(4):2949-2956. Epub 2020 Feb 27. PMID: 32256780
Summary Title:
Ginkgolic acid inhibits the expansion of renal cell carcinoma cells through inactivation of the EGFR signaling pathway.
Summary:
Renal cell carcinoma (RCC) is among the commonest urological malignancies occurring in grownup human kidneys worldwide. Latest analysis on antitumor medicine has centered on plant extracts, a category of compounds that play important roles in most cancers remedy. The current examine aimed to research the potential antitumor impact of ginkgolic acid (GA) in RCC. Transwell invasion assay, cell counting kit-8 assay and stream cytometry had been used to measure cell migration, cell viability and apoptosis, respectively. A community pharmacology strategy was utilized to determine pathway data, combining molecular docking strategies to display for key goal data. Within the current examine, GA inhibited the viability and proliferation of RCC cells (786-O and A498), bothand, through Garrest. GA additionally lowered RCC cell invasion and migration. As well as, the epidermal progress issue receptor (EGFR) was recognized as a important goal protein of GA, which considerably inactivated EGFR signaling in RCC (P
