Ginkgolide B has protecting results on cerebral damage by inhibiting the irritation induced by ischemia/reperfusion damage.
PMID:
Zhong Yao Cai. 2010 Apr ;33(4):578-80. PMID: 20845788
Summary Title:
[Effects of Ginkgolide B on inflammation induced by cerebral ischemia-reperfusion in rats].
Summary:
OBJECTIVE: To research the protecting results of Ginkgolide B on irritation induced by cerebral ischemia-reperfusion in rats.METHODS: Rats had been pretreated with Ginkgolide B on the dose of two. 5, 5, 10 mg/kg for 3 days after which subjected to cerebral ischemia/reperfusion induced by a center cerebral artery occlusion (MCAO). The infarct quantity and the neurological deficit had been decided by the strategy of TTC (2,3,5-triphenylterazolium chloride) staining and Longa’s rating. The permeability of blood-brain barrier (BBB) was evaluated by measurement of the evans blue (EB) content material within the mind with spectrophotometer. The content material of interleukin-1beta, interleukin-6 (IL-6, IL-1beta) in serum and tumor necrosis factor-alpha (TNF-alpha), The content material of E-selectin and ICAM 1 in mind had been decided by radio-immunoassay and ELISA assay.RESULTS: Ginkgolide B lowered infarct quantity, ameliorated the neurological deficit and the permeability of BBB, the content material of IL-6, IL-1beta in serum and TNF-alpha, expressions of E-selectin and ICAM 1 in mind tissue additionally had been considerably decreased.CONCLUSION: Ginkgolide B has protecting results on cerebral damage by inhibiting the irritation induced by ischemia/reperfusion damage.
