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Ginkgolides shield PC12 cells towards hypoxia-induced damage.


J Cell Biochem. 2008 Feb 1 ;103(2):564-75. PMID: 17647269

Summary Title: 

Ginkgolides shield PC12 cells towards hypoxia-induced damage by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding exercise.


We hypothesized that the neuroprotective position of the standardized Ginkgo biloba (Ginkgoaceae) extract EGb 761 underneath hypoxic situations is likely to be related to its perform to extend HIF-1 exercise based mostly on the truth that oxygen availability is essential for mobile metabolism and viability and that HIF-1 performs a necessary position in mobile oxygen homeostasis underneath hypoxic situations. On this research, we due to this fact investigated the consequences of ginkgolides, the primary constituent of the non-flavone fraction of EGb 761, on the content material and exercise of HIF-1alpha, a key issue to find out HIF-1 exercise, in hypoxic PC12 cells induced by cobalt chloride. Our knowledge demonstrated that ginkgolides have a major protecting position towards hypoxia-induced damage within the PC12 cells. The findings additionally strongly help our speculation that the protecting position of ginkgolides is as a result of up-regulation of HIF-1alpha protein expression and modification by means of the ginkgolides-induced activation of the p42/p44 MAPK pathway. As well as, it was evident that ginkgolides may considerably improve the HIF-1 DNA binding exercise, which could even be related to the protecting results of ginkgolides by selling the expression of goal genes of HIF-1 underneath hypoxic situations.

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