PMID:
Antioxidants (Basel). 2023 Aug 7 ;12(8). Epub 2023 Aug 7. PMID: 37627571
Summary Title:
Ginsenoside Rc, an Lively Part of, Alleviates Oxidative Stress-Induced Muscle Atrophy through Enchancment of Mitochondrial Biogenesis.
Summary:
Lack of skeletal muscle mass and performance has detrimental results on high quality of life, morbidity, and mortality, and is especially related in getting old societies. The enhancement of mitochondrial operate has proven promise in selling muscle differentiation and performance. Ginsenoside Rc (gRc), a significant element of ginseng, has numerous pharmacological actions; nonetheless, its impact on muscle loss stays poorly explored. On this examine, we examined the consequences of gRc on the hydrogen peroxide (HO)-induced discount of cell viability in C2C12 myoblasts and myotubes and HO-induced myotube degradation. As well as, we investigated the consequences of gRc on the manufacturing of intracellular reactive oxygen species (ROS) and mitochondrial superoxide, ATP technology, and peroxisome proliferator-activated receptor-gamma co-activator 1α(PGC-1α) exercise in myoblasts and myotubes underneath HOtreatment. Moreover, to elucidate the mechanism of motion of gRc, we performed a transcriptome evaluation of myotubes handled with or with out gRc underneath HOtreatment. gRc successfully suppressed HO-induced cytotoxicity, intracellular ROS, and mitochondrial superoxide manufacturing, restored PGC-1αpromoter exercise, and elevated ATP synthesis. Furthermore, gRc considerably affected the expression ranges of genes concerned in sustaining mitochondrial mass and biogenesis, whereas downregulating genes related to muscle degradation in C2C12 myotubes underneath oxidative stress. We offer compelling proof supporting the potential of gRc as a promising remedy for muscle loss and weak point. Additional investigations of the pharmacological results of gRc underneath numerous pathological situations of muscle loss will contribute to the medical growth of gRc as a therapeutic intervention.
