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Excessive-intensity statins underused with atherosclerotic heart problems

High-intensity statins underused with atherosclerotic cardiovascular disease

Amongst sufferers with atherosclerotic heart problems (ASCVD), high-intensity statins are underutilized in routine care, in keeping with a examine revealed on-line Aug. 2 in Circulation: Cardiovascular High quality and Outcomes.

Ann Marie Navar, M.D., Ph.D., from College of Texas Southwestern Medical Heart in Dallas, and colleagues examined use of statins and different lipid-lowering remedy (LLT) and adjustments in (LDL-C) amongst sufferers with ASCVD. The evaluation included digital well being record-derived information from outpatient visits for 322,153 sufferers with ASCVD (Cerner Actual-World Information from 92 U.S. well being methods 2017 by means of 2018).

The researchers discovered that 76.1 % of sufferers have been on statins, with solely 39.4 % on high-intensity statins. In contrast with ladies, males have been extra prone to obtain high-intensity statins (multivariable-adjusted odds ratio [OR], 1.34). Decrease odds of statin use have been seen with growing age (OR, 0.79 per five-year enhance at 60 years). In contrast with sufferers with , sufferers with (OR, 0.40) and (OR, 0.75) had decrease odds of utilizing high-intensity statins. Most sufferers (61.3 %) at baseline had elevated LDL-C (≥70 mg/dL), together with 59.8 % of these on low/moderate-intensity statins and 76.1 % on no statin. At one 12 months, solely 45.3 % achieved an LDL-C <70 mg/dL. Nonstatin LLT use was low. Amongst sufferers on no statin or low/moderate-intensity statin at baseline, at one 12 months, 14.8 and 13.4 %, respectively, have been on high-intensity statins.

“Concerted efforts are needed to address therapeutic inertia for lipid management in patients with ASCVD,” the authors write.

A number of authors disclosed ties to the pharmaceutical trade.

Extra data:
Ann Marie Navar et al, Gaps in Guideline-Primarily based Lipid-Decreasing Remedy for Secondary Prevention in america: A Retrospective Cohort Research of 322 153 Sufferers, Circulation: Cardiovascular High quality and Outcomes (2023). DOI: 10.1161/CIRCOUTCOMES.122.009787

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Excessive-intensity statins underused with atherosclerotic heart problems (2023, September 19)
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