J Nanobiotechnology. 2023 Mar 21 ;21(1):99. Epub 2023 Mar 21. PMID: 36941611
Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration through enhancing autophagy in nucleus pulposus cells.
Extreme reactive oxygen species (ROS) in nucleus pulposus cells (NPCs) promote extracellular matrix (ECM) degradation and mobile inflammatory responses by activating quite a lot of mobile pathways, in the end inducing cell apoptosis and resulting in the event of low again ache. Right here, we designed and fabricated an isoginkgetin-loaded ROS-responsive supply system (IGK@SeNP) based mostly on diselenide block copolymers. Efficiently encapsulated IGK was launched intelligently and quickly in a microenvironment with excessive ROS ranges in degenerative disc. Managed-release IGK not solely effectively scavenged ROS from the intervertebral disc along with diselenide block copolymers but in addition successfully enhanced autophagy in NPCs to inhibit ECM degradation and cell apoptosis, and confirmed important therapeutic results within the rat intervertebral disc degeneration (IDD) mannequin. Total, the synergistic results of IGK@SeNP in ROS scavenging and autophagy enhancement endowed it with a gorgeous therapeutic technique for IDD therapy.