Low ranges of serum and intracellular vitamin C in hospitalized COVID-19 sufferers.
PMID:
Vitamins. 2023 Aug 20 ;15(16). Epub 2023 Aug 20. PMID: 37630843
Summary Title:
Low Ranges of Serum and Intracellular Vitamin C in Hospitalized COVID-19 Sufferers.
Summary:
Vitamin C is an important micronutrient for human immune cell operate and has potent antioxidant properties. It’s hypothesized that vitamin C serum ranges decline throughout an infection. Nevertheless, the exact mechanisms stay unknown. To realize deeper insights into the true position of vitamin C throughout infections, we aimed to judge the physique’s vitamin C storage throughout a SARS-CoV-2 an infection. On this single-center research, we examined serum and intracellular vitamin C ranges in peripheral blood mononuclear cells (PBMCs) of 70 hospitalized COVID-19 sufferers on the primary and fifth days of hospitalization. Additionally, medical COVID-19 severity was evaluated at these timepoints. Our findings revealed a excessive prevalence of hypovitaminosis C and vitamin C deficiency in hospitalized COVID-19 sufferers (36% and 15%). Furthermore, sufferers with extreme or vital illness exhibited a better prevalence of low serum vitamin C ranges than these with average sickness. Serum vitamin C ranges had a weak unfavourable correlation with medical COVID-19 severity classification on the day of hospitalization; nevertheless, there was no correlation with intracellular vitamin C. Intracellular vitamin C ranges had been decreased on this cohort as in comparison with a wholesome cohort and confirmed additional decline throughout hospitalization, whereas serum ranges confirmed no related change. Primarily based on this commentary, it may be steered that the discount of intracellular vitamin C could also be attributed to its antioxidative operate, the necessity for replenishing serum ranges, or enhanced turnover by immune cells. These information give an incentive to additional examine the position of intracellular vitamin C in a bigger and extra heterogeneous cohort in addition to the underlying mechanisms.
