Mechanism and dose-effect of Ginkgolide B on extreme acute pancreatitis.
PMID:
World J Gastroenterol. 2011 Could 7 ;17(17):2241-7. PMID: 21633536
Summary Title:
Mechanism and dose-effect of Ginkgolide B on extreme acute pancreatitis of rats.
Summary:
AIM: To find out the optimum dosage and mechanism of Ginkgolide B (BN52021) on extreme acute pancreatitis (SAP) of rats.METHODS: Seventy male Wistar rats have been randomly divided into seven teams (10 for every group). Sham-operation group (SO), SAP mannequin group (SAP), dimethyl sulfoxide (DMSO) distinction group (DMSO), and teams handled with 2.5 mg/kg BN52021 (BN1), 5 mg/kg BN52021 (BN2), 10 mg/kg BN52021 (BN3), and 20μg/kg Sandostatin (SS). The SAP mannequin was established in Wistar rats by injecting 5% sodium taurocholate retrogradely into the frequent bilio-pancreatic duct. The rats of SO, DMSO and BN52021 have been injected with 0.9% NaCl, 0.5% DMSO and BN52021 by way of femoral vein 15 min after the operation. The SS group was injected with Sandostatin subcutaneously. All rats have been anaesthetized at 6 h after operation, and venous blood was collected to find out the degrees of serum amylase and phospholipase A2 (PLA₂), and pancreas tissue was harvested and stained.RESULTS: There was no important distinction between the SAP and DMSO teams in serum amylase degree, PLA₂, ascites and pathologic rating, however important distinction was present in SAP/DMSO teams in contrast with these in SO group (P
