Entrance Getting older Neurosci. 2023 ;15:1227513. Epub 2023 Aug 4. PMID: 37600520
Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion damage.
Cerebral ischemia-reperfusion (CIR) damage is initiated by the technology of reactive oxygen species (ROS), which results in the oxidation of mobile proteins, DNA, and lipids as an preliminary occasion. The reperfusion course of impairs crucial cascades that assist cell survival, together with mitochondrial biogenesis and antioxidant enzyme exercise. Failure to activate prosurvival indicators might end in elevated neuronal cell demise and exacerbation of CIR injury. Melatonin, a hormone produced naturally within the physique, has excessive concentrations in each the cerebrospinal fluid and the mind. Nevertheless, melatonin manufacturing declines considerably with age, which can contribute to the event of age-related neurological issues attributable to lowered ranges. By activating varied signaling pathways, melatonin can have an effect on a number of points of human well being attributable to its various vary of actions. Due to this fact, understanding the underlying intracellular and molecular mechanisms is essential earlier than investigating the neuroprotective results of melatonin in cerebral ischemia-reperfusion damage.