Modulation of oxidative stress by Chlorella vulgaris in streptozotocin (STZ) induced diabetes.
PMID:
Adv Med Sci. 2010 ;55(2):281-8. PMID: 21147697
Summary Title:
Modulation of oxidative stress by Chlorella vulgaris in streptozotocin (STZ) induced diabetic Sprague-Dawley rats.
Summary:
PURPOSE: Chlorella vulgaris (CV), a contemporary water alga has been reported to have hypoglycemic results. Nevertheless, antioxidant and anti inflammatory results of CV in diabetic animals haven’t been investigated thus far. The purpose of the current research was to analyze the function of CV in irritation and oxidative harm in STZ-induced diabetic rats.MATERIALS AND METHODS: Male Sprague-Dawley rats (300 – 400g) have been divided into 4 teams: management, CV, STZ-induced diabetic rats, and STZ rats handled with CV (150mg/kg physique wt). Blood samples have been drawn from orbital sinus at 1 and 4 weeks for dedication of oxidative mobile harm (DNA harm and lipid peroxidation [malondialdehyde, MDA]), irritation (tumour necrosis issue alpha, TNF-α) and antioxidant standing (catalase, CAT, and superoxide dismutase, SOD).RESULTS: CV didn’t have any results on glucose ranges in diabetic rats, over the 4 weeks of therapy. Nevertheless, it decreased considerably DNA harm and blood MDA ranges in STZ-induced diabetic rats in comparison with the management group. Plasma ranges of TNF-αhowever didn’t present any important modifications in STZ-induced diabetic rats fed with CV. Antioxidant enzyme SOD confirmed no important modifications in all teams however CAT exercise was decreased in STZ-induced diabetic rats in comparison with the management.CONCLUSIONS: CV didn’t have hypoglycaemic impact but it surely has a protecting function in STZ-induced diabetic rats by lowering oxidative DNA harm, and lipid peroxidation.
