Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 29. Epub 2023 Jul 29. PMID: 37515736
Protecting position of vitamin E in opposition to acrylamide-induced testicular toxicity from being pregnant to maturity: insights into oxidative stress and aromatase regulation.
Acrylamide (ACR) is a poisonous chemical incessantly encountered in every day life, posing well being dangers. This examine aimed to elucidate the molecular-level mechanism of ACR’s poisonous results on testicles and examine whether or not Vitamin E can mitigate these results. A complete of 40 grownup pregnant rats have been utilized, divided into 4 teams: Management, ACR, Vitamin E, and ACR + Vitamin E. ACR and Vitamin E have been administered to the mom rats throughout being pregnant and lactation, and to the male offspring till the eighth week post-birth. Serum hormone ranges, oxidant-antioxidant parameters, histopathological examination of testicular tissue, and mRNA and protein ranges of the testicular and liver aromatase gene have been analyzed. Spermiogram evaluation was carried out on the collected sperm samples from the male offspring. The outcomes revealed that ACR publicity adversely affected hormone ranges, oxidant-antioxidant parameters, histological findings, in addition to aromatase gene and protein expressions. Nonetheless, Vitamin E administration successfully prevented the poisonous results of ACR. These findings exhibit that ACR software considerably impairs the reproductive efficiency of male offspring rats by rising liver aromatase exercise.