Position of δ-tocotrienol and resveratrol supplementation within the regulation of micro RNAs in sufferers with metabolic syndrome.
PMID:
Complement Ther Med. 2023 Jun ;74:102950. Epub 2023 Apr 20. PMID: 37086927
Summary Title:
Position ofδ-tocotrienol and resveratrol supplementation within the regulation of micro RNAs in sufferers with metabolic syndrome: A randomized managed trial.
Summary:
OBJECTIVE: To find out the impact ofδ-tocotrienol and resveratrol combination (TRM) supplementation compared to placebo for twenty-four weeks, on the relative expression of miRNAs (miRNA-130b-5p, miRNA-221-5p, miR-15b-5p, miRNA-122-5p, and miRNA-376b-5p) in sufferers with Metabolic syndrome (MetS).DESIGN: This randomized placebo-controlled trial was carried out on the tertiary care institute of the NUMS, Rawalpindi, Pakistan. A complete of 82 grownup MetS sufferers had been enrolled and randomly grouped into the TRM group (n = 41) and the Placebo group (n = 41). Sufferers within the TRM group got 400 mg capsules (δ-tocotrienol 250 mg; Resveratrol 150 mg) and placebo obtained (cellulose 400 mg capsule) twice each day for twenty-four weeks.RESULTS: The TRM supplementation revealed a major (p
