The protecting results of ginkgolide B and hypoxic preconditioning in opposition to acute hypoxia harm.
PMID: Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 Aug ;25(3):362-5. PMID: 21155236 Summary Title:
[The protective effects of ginkgolide B and hypoxic preconditioning against acute hypoxia injury in mice].
Summary:
AIM: To analyze the protecting results of ginkgolide B and hypoxic preconditioning in opposition to acute hypoxia harm in mice.METHODS: Peculiar strain acute hypoxia mannequin in mice was adopted to watch the ethology, the length of the loss of life and the diploma of mind edema. In the meantime the expression of RTP801 mRNA and erythropoietin (EPO) have been measured by RT-PCR and Western blot, respectively.RESULTS: Ginkgolide B and hypoxic preconditioning might each delay the survival time of hypoxia below peculiar strain,and considerably decreased the diploma of mind edema. Moreover ginkgolide B and hypoxic preconditioning might each up-regulate the expression of RTP801mRNA and EPO.CONCLUSION: Ginkgolide B has the same impact to hypoxic preconditioning in opposition to acute hypoxia. Each of those protecting results could also be related to the up-regulation of the expression of RTP801 mRNA and EPO.
